Mitochondrial Metabolic Inhibition and Cardioprotection
نویسندگان
چکیده
منابع مشابه
Mitochondrial Metabolic Inhibition and Cardioprotection
Reperfusion is needed to initiate reflow of blood in cardiac arrest triggered by surgical intervention or pathologically-induced cardiac ischemia. However, subsequent reperfusion may lead not only to the recovery of ischemic cardiac tissue, but also to the paradoxical phenomenon of myocardial ischemia/reperfusion (IR) injury, including protracted organ recovery, myocardial stunning, and acute m...
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Ischaemic preconditioning confers strong protection against myocardial ischaemia–reperfusion injury. Although its therapeutic application in the case of acute coronary syndromes is not possible in general, the cellular and molecular processes leading to preconditioning protection may be of interest for the designing of cardioprotective therapies. Many cellular processes have been shown to be in...
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Our laboratory has previously reported that acetaminophen confers functional cardioprotection following cardiac insult, including ischemia/reperfusion, hypoxia/reoxygenation, and exogenous peroxynitrite administration. In the present study, we further examined the mechanism of acetaminophen-mediated cardioprotection following ischemia/reperfusion injury. Langendorff-perfused guinea pig hearts w...
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BACKGROUND Cardiovascular risk factors, including diabetes mellitus may attenuate the cardioprotection by postconditioning. This study aimed to investigate the cardioprotective effect of ischemic-postconditioning (IPostC) against ischemia/reperfusion injury in normal and chronically type-1 diabetic rats and the effect of mitochondrial permeability transition pore (mPTP) inhibition in this field...
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ژورنال
عنوان ژورنال: Korean Circulation Journal
سال: 2017
ISSN: 1738-5520,1738-5555
DOI: 10.4070/kcj.2016.0401